The revolutionary 4D Organ-on-chip platform
What is ReleGO™️ & REVex™️ platform ?
ReleGO™ is the world’s first 4D skin testing platform which functions as a fraction collector that automates procedures with liquid handling and time-based sampling, ReleGO™ accommodates four REVex™ chips — single-use microfluidic devices for testing the safety and efficacy of chemicals, active ingredients, and product formulations on tissue explants or simulants. Each chip has 3 chambers, allowing as many as 12 unique tests to be run simultaneously. Additionally, because protocols are automated, the product also eliminates the need for tiresome, labor-intensive sampling processes.
ReleGO™
FULLY AUTOMATED & PROGRAMMABLE
FRACTION COLLECTOR
REVex™
SKIN-ON-CHIP
COMPATIBLE WITH HUMAN EXPLANTS, COMMERCIAL RECONSTRUCTED SKIN SIMULANTS, SYNTHETIC MEMBRANES AND OTHER TISSUES
How to use ReleGO™ and REVex™ chips?
Before ReleGO™, skin researchers faced time-consuming manual operations with traditional diffusion cell apparatus, leading to high costs, accuracy issues, and inconsistencies. REVIVO BioSystems solves these problems by mimicking blood flow function, providing a steady supply of nutrients and oxygen to cells while removing metabolic by-products. REVex™, in a miniaturized size, requires only one-fifth of the sample size compared to traditional methods.
APPLICATION
Looking for a guideline for your own application with ReleGo microfluidic system?
FREQUENTLY ASKED QUESTIONS
A: Due to Limitations on 2D cultures and 3D organ models, other new technologies such as microfabrication for biological purposes have been created. This approach directed to the development of the so-called organs-on-chips. These are microfluidic devices with micron size chambers that allow the dynamic culture of cells inside, in order to simulate or mimic the physiology of a tissue or organ. It is possible to apply various physical or chemical stimuli on the tissue inside the chip and simulate the body environment.
The possibility of applying different physical or chemical stimuli to the tissue inside the chip might help with the recreation of its physiology in a more accurate manner than that of a static and traditional 3D culture, having a better control of the cell microenvironment.
A: It’s a novel model to drive productivity up and cost down, while more importantly moving away from cruel and animal-based testing and working with ex-vivo human tissue explants or in vitro tissue engineered models.. ReleGO™ is fully automated and easy-to-use platform, mimicking in-vivo-like conditions for your safety, efficacy, and permeation studies.
A: What makes ReleGO™ & REVex™ chip so easy to adopt is that they are fully compatible with a wide range of skin simulants and skin tissue models!
ReleGO™ & REVex™ have been tested to be fully compatible with real skin explants, commercially available organotypic skin cultures, animal skin and synthetic membranes, making the platform easy and convenient for you to adapt to your current project needs.
A: Both ReleGO™ and REVex™ are engineered with the highest precision to take on a diverse range of in vitro and ex vivo tests:
✔️Product Efficacy tests for marketing & label claims:
Anti-Aging,
Anti-pigmentation,
Integrity of skin barrier,
Oxidative Stress,
Anti-pollution,
Wound healing
✔️ Permeation studies:
Transdermal delivery studies,
In Vitro Skin Absorption (OECD 428),
In Vitro Release Testing (IVRT)
✔️ Safety test for ingredients and product formulation:
Irritation,
Corrosion,
Toxicity & Phototoxicity
More questions about Organ on chip & microfluidic solutions?
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